Isopropanol → Cefadroxil hemihydrate

Participants

Reaction Conditions

Reaction Steps

Cefadroxil 1-methyl-2-pyrrolidone solvate (30 g) was slurried in a mixture of metahnol (80 ml), isopropyl alcohol (60 ml) and water (10 ml) at 50° C. for 90'. After cooling to 10° C. the mixture was filtered, the product washed with acetone and dried at 40° C. to yield 19.1 g of crystalline cefadroxil hemihydrate.

Provenance & Evidence