Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(Chloromethyl)-6-methoxypyrimidin-2-amine → 2-Amino-4-methoxy-6-dimethylthiocarbamoylthiomethyl-pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(Chloromethyl)-6-methoxypyrimidin-2-amine | HCID 13884815 | — |
| 반응물 | Sodium dimethyldithiocarbamate dihydrate | HCID 23693613 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-Amino-4-methoxy-6-dimethylthiocarbamoylthiomethyl-pyrimidine | HCID 20070829 | — |
반응 단계
18.5 g of dimethyldithiocarbamic acid sodium salt dihydrate and 17.4 g of 2-amino-4-chloromethyl-6-methoxy-pyrimidine are refluxed in 100 ml of ethanol for 30 minutes. After the mixture has been cooled, it is diluted with about 1 liter of water, and the product which has precipitated is separated and dried. The yield is 23.0 g (89% of theory) of 2-amino-4-methoxy-6-dimethylthiocarbamoylthiomethyl-pyrimidine, m.p. 118°-120° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04904783 |
| 출처 데이터셋 | uspto-grants-1990_02 |
| ORD ID | ord-59b9a875c81c4c5b9d6135f855b892bb |
| 출처 메모 | uspto-grants-1990_02 |