HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 19864853, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-(Chloromethyl)quinoline | HCID 20394 | — |
| Reactant | 3-(1,3-Dioxolan-2-yl)phenol | HCID 13280119 | — |
| Catalyst | Potassium Iodide | HCID 4875 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 19864853 | HCID 19864853 | 74% |
Reaction Steps
A solution of the ketal of Step A, above, (10 g, 0.06 mol), 2-chloromethylquinoline (10.6 g, 0.06 mol), cesium carbonate (20.0 g, 0.06 mol) and potassium iodide (0.16 g, 0.001 mol) in 250 ml acetone is refluxed 20 hours. The solution is filtered through Celite and silica gel and the solvent is removed in vacuo. The resulting crude solid is recrystallized using 2-propanol to give 13.7 g of crystalline solid (74% yield) m.p. 67°-69° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04904786 |
| Source dataset | uspto-grants-1990_02 |
| ORD ID | ord-3dcfdd0f16e14ffb833bea4784816fe0 |
| Source note | uspto-grants-1990_02 |