(+-)-Pantolactone → Keto-pantoyllactone

HRID 1200266Notes

Reaction equation

HRID 1200266 reaction equation
[CH3:1][C:2]1([CH3:9])[CH:7]([OH:8])[C:5](=[O:6])[O:4][CH2:3]1>[O-2].[O-2].[O-2].[O-2].[O-2].[V+5].[V+5]>[CH3:1][C:2]1([CH3:9])[C:7](=[O:8])[C:5](=[O:6])[O:4][CH2:3]1

Participants

3

Reactant 1

HCID 989(+-)-Pantolactone2×

Product 1

HCID 39Keto-pantoyllactone

Reagents, catalysts & solvents 1

HCID 178419084HCID 178419084, compoundCatalyst

Procedure

α-Aluminium oxide coated with 10% vanadium pentoxide (V-0501S from Harshaw) is used as the catalyst in the reactor described in Example 1 and the temperature of the air bath is adjusted to 245° C. 60 l of air and 33 g of pantolactone are subsequently added hourly to the evaporator. 99% of the pantolactone are transformed and ketopantolactone is formed with a selectivity of 85%.

Workup

  1. customis adjusted to 245° C

Sources & evidence

ORD record
ord-8473ef2f4bf9423ba3632eefe96512f4
Source dataset
uspto-grants-1990_02
Patent number
US04904805

Reaction notes

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