(+-)-Pantolactone → Keto-pantoyllactone

HRID 1200268Notes

Reaction equation

HRID 1200268 reaction equation
[CH3:1][C:2]1([CH3:9])[CH:7]([OH:8])[C:5](=[O:6])[O:4][CH2:3]1>[O-2].[V].[Ni]>[CH3:1][C:2]1([CH3:9])[C:7](=[O:8])[C:5](=[O:6])[O:4][CH2:3]1

Participants

3

Reactant 1

HCID 989(+-)-Pantolactone2×

Product 1

HCID 39Keto-pantoyllactone

Reagents, catalysts & solvents 1

HCID 17116752502-12-2Catalyst

Procedure

Nickel vanadate on ceramic is used as the catalyst in the reactor described in Example 1 and the temperature of the air bath is adjusted to 270° C. 100 l of air and 32 g of pantolactone are subsequently added hourly to the evaporator. 99.2% of the pantolactone are transformed and ketopantolactone is formed with a selectivity of 79.8%.

Workup

  1. customis adjusted to 270° C

Sources & evidence

ORD record
ord-d92b71fcef004a45ad8e841da5a7594d
Source dataset
uspto-grants-1990_02
Patent number
US04904805

Reaction notes

Loading…