(+-)-Pantolactone → Keto-pantoyllactone

HRID 1200270Notes

Reaction equation

HRID 1200270 reaction equation
[CH3:1][C:2]1([CH3:9])[CH:7]([OH:8])[C:5](=[O:6])[O:4][CH2:3]1>[O-][V](=O)=O.[Ag+]>[CH3:1][C:2]1([CH3:9])[C:7](=[O:8])[C:5](=[O:6])[O:4][CH2:3]1

Participants

3

Reactant 1

HCID 989(+-)-Pantolactone2×

Product 1

HCID 39Keto-pantoyllactone

Reagents, catalysts & solvents 1

HCID 308415513497-94-4Catalyst

Procedure

Silver vanadate on ceramic is used as the catalyst in the reactor described in Example 1 and the temperature of the air bath is adjusted to 250° C. 60 l of air and 27 g of pantolactone are subsequently added hourly to the evaporator. 98.4% of the pantolactone are transformed and ketopantolactone is formed with a selectivity of 84.4%.

Workup

  1. customis adjusted to 250° C

Sources & evidence

ORD record
ord-bd2c576fe5b9427f937cfb92949c789d
Source dataset
uspto-grants-1990_02
Patent number
US04904805

Reaction notes

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