3156-74-9 → HCID 178523872, compound

HRID 1200273Notes

Reaction equation

HRID 1200273 reaction equation
[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:52])[C@H:21]([CH2:46][C:47]2[N:51]=[CH:50][NH:49][CH:48]=2)[NH:22][C:23](=[O:45])[CH:24]([CH2:34][C:35]2[C:44]3[C:39](=[CH:40][CH:41]=[CH:42][CH:43]=3)[CH:38]=[CH:37][CH:36]=2)[CH2:25][C:26](=[O:33])[N:27]2[CH2:32][CH2:31][O:30][CH2:29][CH2:28]2)[CH:9]([OH:18])[CH2:10][S:11][C:12]2[S:13][C:14]([CH3:17])=N[N:16]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C1(C[C@H](NC(=O)[C@H](CC2N=CNC=2)NC(=O)C(CC2C3C(=CC=CC=3)C=CC=2)CC(=O)N2CCOCC2)C(O)CSC2SN=NC=2)CCCCC1.C(N1C(SCC(O)CC)=NN=N1)C.CN1C(S(CC(O)CC)(=O)=O)=NN=N1.[N+](CC(O)CC)([O-])=O>>[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:52])[C@H:21]([CH2:46][C:47]2[N:51]=[CH:50][NH:49][CH:48]=2)[NH:22][C:23](=[O:45])[CH:24]([CH2:34][C:35]2[C:44]3[C:39](=[CH:40][CH:41]=[CH:42][CH:43]=3)[CH:38]=[CH:37][CH:36]=2)[CH2:25][C:26](=[O:33])[N:27]2[CH2:28][CH2:29][O:30][CH2:31][CH2:32]2)[CH:9]([OH:18])[CH2:10][S:11][C:12]2[S:13][CH:14]=[CH:17][N:16]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

6

Reactant 5

HCID 955383156-74-9HCID 86743776HCID 86743776, compoundHCID 86743777HCID 86743777, compoundHCID 178434149HCID 178434149, compoundHCID 178523871HCID 178523871, compound

Product 1

HCID 178523872HCID 178523872, compound

Procedure

(3S)-4-cyclohexyl-3-[(N-[1,4-dioxo-4-morpholino-2-(1-naphthylmethyl)butyl]-L-histidyl]amino]-1-[(5-methyl-1,3,4-thiadiazol-2-yl)thio]-2-butanol; (3S0-4-cyclohexyl-3-[(N-[1,4-dioxo-4-morpholino-2-(1-naphthylmethyl)butyl]-L-histidinyl]amino]-1-(2-pyrimidinylthio)-2-butanol; (3S)-4-cyclohexyl-3-[(N-[1,4-dioxo-4-morpholino-2-(1-naphthylmethyl)butyl]-L-histidyl]amino]-1-(1,2,3-thiadiazol-5-ylthio]-2-butanol; (3S)-cyclohexyl-3-[(N-[1,4-dioxy-2-(1-naphthylmethyl)-4-(3-thienyl)butyl]-L-histidyl]amino]-1-(1-methyl-5-tetrazolyl)-2-butanol; (3S)-4-cyclohexyl-3-[(N-[1,4-dioxo-4-morpholino)-2-(1-naphthyl)butyl]-L-histidyl]amino]-1-[(1-ethyl-5-tetrazolyl)thio]-2-butanol; (3S)-4-cyclohexyl-3-[(N-1,4-dioxo-4-morpholino)-2-(1-naphthylmethyl)butyl]-L-histidyl]amino]-1-[(1-methyl-5-tetrazolylsulfonyl] -2-butanol; and (3S)-4-cyclohexyl-3-[(N-[1,4-dioxo-4-morpholino)-2-(1-naphthylmethyl)butyl]-L-histidyl]amino]-1-nitro-2-butanol.

Sources & evidence

ORD record
ord-dc6cbe2b28f248c0b0da26b43e0e741b
Source dataset
uspto-grants-1990_02
Patent number
US04904660

Reaction notes

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