Dichloromethane → 5-(Chloromethyl)-2,2-difluorobenzo[d][1,3]dioxole

HRID 1200312Notes

Reaction equation

HRID 1200312 reaction equation
[Cl:18][CH2:19][Cl:20].[F:5][C:6]1([F:17])[O:7][c:8]2[c:9]([cH:11][cH:12][c:13]([CH2:15][OH:16])[cH:14]2)[O:10]1.[S:1]([Cl:2])([Cl:3])=[O:4]>>[Cl:3][CH2:15][c:13]1[cH:12][cH:11][c:9]2[c:8]([cH:14]1)[O:7][C:6]([F:5])([F:17])[O:10]2

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 24386Thionyl ChlorideHCID 12814281(2,2-Difluoro-1,3-dioxaindan-5-yl)methanol

Product 1

HCID 219928095-(Chloromethyl)-2,2-difluorobenzo[d][1,3]dioxole

Sources & evidence

ORD record
ord-87de75b3b0c245d29c577f23ca3690e7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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