Ammonium → 1,1-dimethylethyl 4-(4-amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-piperidinecarboxylate

HRID 1200574Notes

Reaction equation

HRID 1200574 reaction equation
[Br:1][c:2]1[cH:3][n:4]([CH:12]2[CH2:13][CH2:14][N:15]([C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH2:16][CH2:17]2)[c:5]2[n:6][cH:7][n:8][c:9]([Cl:11])[c:10]12.[CH2:27]1[O:28][CH2:29][CH2:30][O:31][CH2:32]1.[NH4+:25].[OH-:26]>>[Br:1][c:2]1[cH:3][n:4]([CH:12]2[CH2:13][CH2:14][N:15]([C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH2:16][CH2:17]2)[c:5]2[n:6][cH:7][n:8][c:9]([NH2:25])[c:10]12

Participants

5

Reactant 4

HCID 223AmmoniumHCID 961HydroxideHCID 312751,4-DioxaneHCID 580578901,1-dimethylethyl 4-(5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-piperidinecarboxylate

Product 1

HCID 668237951,1-dimethylethyl 4-(4-amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-piperidinecarboxylate

Sources & evidence

ORD record
ord-d4d463d95a43469ca0434648618e11a9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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