Ethanol → (3aRS,4RS,7aSR)-4-(2-methoxyphenyl)-4-perhydroisoindolol

HRID 1200998Notes

Reaction equation

HRID 1200998 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH:10]2[CH2:11][CH2:12][CH2:13][C:14]([OH:17])([c:18]3[c:19]([O:24][CH3:25])[cH:20][cH:21][cH:22][cH:23]3)[CH:15]2[CH2:16]1.[CH3:29][CH2:30][OH:31].[OH-:26].[OH-:28].[Pd+2:27]>>[NH:8]1[CH2:9][CH:10]2[CH2:11][CH2:12][CH2:13][C:14]([OH:17])([c:18]3[c:19]([O:24][CH3:25])[cH:20][cH:21][cH:22][cH:23]3)[CH:15]2[CH2:16]1

Participants

5

Reactant 4

HCID 702EthanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 67713984(3aRS,4RS,7aSR)-2-benzyl-4-(2-methoxyphenyl)-4-perhydroisoindolol

Product 1

HCID 67713920(3aRS,4RS,7aSR)-4-(2-methoxyphenyl)-4-perhydroisoindolol

Sources & evidence

ORD record
ord-ab68919fa2f3402ab25eacd6542f738b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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