3-(2-Bromo-3-pyridyl)isoxazole → 2-Chloro-4,4-difluoro-1'-[[1-(3-isoxazol-3-yl-2-pyridyl)-3-methyl-pyrazol-4-yl]methyl]spiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]

HRID 1201287Notes

Reaction equation

HRID 1201287 reaction equation
[Br:25][c:26]1[n:27][cH:28][cH:29][cH:30][c:31]1-[c:32]1[n:33][o:34][cH:35][cH:36]1.[Cl:1][c:2]1[cH:3][c:4]2[c:5]([s:24]1)[C:6]1([O:7][CH2:8][C:9]2([F:10])[F:11])[CH2:12][CH2:13][N:14]([CH2:17][c:18]2[c:19]([CH3:23])[n:20][nH:21][cH:22]2)[CH2:15][CH2:16]1>>[Cl:1][c:2]1[cH:3][c:4]2[c:5]([s:24]1)[C:6]1([O:7][CH2:8][C:9]2([F:10])[F:11])[CH2:12][CH2:13][N:14]([CH2:17][c:18]2[c:19]([CH3:23])[n:20][n:21](-[c:26]3[n:27][cH:28][cH:29][cH:30][c:31]3-[c:32]3[n:33][o:34][cH:35][cH:36]3)[cH:22]2)[CH2:15][CH2:16]1

Participants

3

Reactant 2

HCID 582685393-(2-Bromo-3-pyridyl)isoxazoleHCID 178434546HCID 178434546, compound

Product 1

HCID 582686132-Chloro-4,4-difluoro-1'-[[1-(3-isoxazol-3-yl-2-pyridyl)-3-methyl-pyrazol-4-yl]methyl]spiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]

Sources & evidence

ORD record
ord-821fe9bdf3c24c15b0f50adba5cf5ce3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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