Dimethyl Sulfoxide → Tert-butyl 4-(3-hydroxypyrrolidin-1-yl)benzoate

HRID 1201542Notes

Reaction equation

HRID 1201542 reaction equation
[C:21](=[O:22])([O-:23])[O-:24].[CH3:28][S:29]([CH3:30])=[O:31].[F:1][c:2]1[cH:3][cH:4][c:5]([C:6](=[O:7])[O:8][C:9]([CH3:10])([CH3:11])[CH3:12])[cH:13][cH:14]1.[K+:25].[K+:26].[NH:15]1[CH2:16][CH:17]([OH:20])[CH2:18][CH2:19]1.[OH2:27]>>[c:2]1([N:15]2[CH2:16][CH:17]([OH:20])[CH2:18][CH2:19]2)[cH:3][cH:4][c:5]([C:6](=[O:7])[O:8][C:9]([CH3:10])([CH3:11])[CH3:12])[cH:13][cH:14]1

Participants

7

Reactant 6

HCID 679Dimethyl SulfoxideHCID 813Potassium Cation2×HCID 962WaterHCID 19660Carbonate IonHCID 982104-HydroxypyrrolidineHCID 2736444Tert-butyl 4-fluorobenzoate

Product 1

HCID 10084125Tert-butyl 4-(3-hydroxypyrrolidin-1-yl)benzoate

Sources & evidence

ORD record
ord-25893d5a05cb41eb883a56a2bbe41319
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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