Potassium Cation → (3',5'-Dichloro-4'-hydroxymethyl-biphenyl-4-yl)-(4-trifluoromethyl-piperidin-1-yl)-methanone

HRID 1201887Notes

Reaction equation

HRID 1201887 reaction equation
[C:32](=[O:33])([O-:34])[O-:35].[CH3:38][OH:39].[Cl:1][c:2]1[cH:3][c:4](-[c:14]2[cH:15][cH:16][c:17]([C:20](=[O:21])[N:22]3[CH2:23][CH2:24][CH:25]([C:28]([F:29])([F:30])[F:31])[CH2:26][CH2:27]3)[cH:18][cH:19]2)[cH:5][c:6]([Cl:13])[c:7]1[CH2:8][O:9][C:10](=[O:11])[CH3:12].[K+:36].[K+:37]>>[Cl:1][c:2]1[cH:3][c:4](-[c:14]2[cH:15][cH:16][c:17]([C:20](=[O:21])[N:22]3[CH2:23][CH2:24][CH:25]([C:28]([F:29])([F:30])[F:31])[CH2:26][CH2:27]3)[cH:18][cH:19]2)[cH:5][c:6]([Cl:13])[c:7]1[CH2:8][OH:9]

Participants

5

Reactant 4

HCID 813Potassium Cation2×HCID 887MethanolHCID 19660Carbonate IonHCID 57672051Acetic acid 3,5-dichloro-4'-(4-trifluoromethyl-piperidine-1-carbonyl)-biphenyl-4-ylmethyl Ester

Product 1

HCID 57672063(3',5'-Dichloro-4'-hydroxymethyl-biphenyl-4-yl)-(4-trifluoromethyl-piperidin-1-yl)-methanone

Sources & evidence

ORD record
ord-85b9476eba944fe48c8fbdd2aeefdc6e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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