3-(2-fluoro-1-fluoromethyl-ethyl)-8-methoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamine → 5-Chloro-N(2)-[3-(2-fluoro-1-fluoromethyl-ethyl)-8-methoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl]-N(4)-(2-methoxy-4-morpholin-4-yl-phenyl)-pyrimidine-2,4-diamine

HRID 120191Notes

Reaction equation

HRID 120191 reaction equation
[Cl:20][c:21]1[n:22][cH:23][c:24]([Cl:42])[c:25]([NH:27][c:28]2[c:29]([O:40][CH3:41])[cH:30][c:31]([N:34]3[CH2:35][CH2:36][O:37][CH2:38][CH2:39]3)[cH:32][cH:33]2)[n:26]1.[F:1][CH2:2][CH:3]([CH2:4][F:5])[N:6]1[CH2:7][CH2:8][c:9]2[c:10]([cH:13][c:14]([NH2:19])[c:15]([O:17][CH3:18])[cH:16]2)[CH2:11][CH2:12]1>>[F:1][CH2:2][CH:3]([CH2:4][F:5])[N:6]1[CH2:7][CH2:8][c:9]2[c:10]([cH:13][c:14]([NH:19][c:21]3[n:22][cH:23][c:24]([Cl:42])[c:25]([NH:27][c:28]4[c:29]([O:40][CH3:41])[cH:30][c:31]([N:34]5[CH2:35][CH2:36][O:37][CH2:38][CH2:39]5)[cH:32][cH:33]4)[n:26]3)[c:15]([O:17][CH3:18])[cH:16]2)[CH2:11][CH2:12]1

Participants

3

Reactant 2

HCID 672643293-(2-fluoro-1-fluoromethyl-ethyl)-8-methoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamineHCID 86633851(2,5-Dichloropyrimidin-4-yl)-(2-methoxy-4-morpholin-4-yl-phenyl)-amine

Product 1

HCID 668306885-Chloro-N(2)-[3-(2-fluoro-1-fluoromethyl-ethyl)-8-methoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl]-N(4)-(2-methoxy-4-morpholin-4-yl-phenyl)-pyrimidine-2,4-diamine

Sources & evidence

ORD record
ord-c78258005f084d69a059a4214bc4a485
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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