2-Aminopyrimidine-5-boronic acid, pinacol ester → 5-[6'-Methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-pyrimidin-2-ylamine

HRID 1201914Notes

Reaction equation

HRID 1201914 reaction equation
[Br:1][c:2]1[cH:3][cH:4][cH:5][c:6](-[c:8]2[n:9][c:10]([CH3:24])[cH:11][c:12](-[c:14]3[cH:15][cH:16][c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]3)[cH:13]2)[n:7]1.[NH2:25][c:26]1[n:27][cH:28][c:29]([B:32]2[O:33][C:34]([CH3:35])([CH3:36])[C:37]([CH3:38])([CH3:39])[O:40]2)[cH:30][n:31]1>>[c:2]1(-[c:29]2[cH:28][n:27][c:26]([NH2:25])[n:31][cH:30]2)[cH:3][cH:4][cH:5][c:6](-[c:8]2[n:9][c:10]([CH3:24])[cH:11][c:12](-[c:14]3[cH:15][cH:16][c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]3)[cH:13]2)[n:7]1

Participants

3

Reactant 2

HCID 177502122-Aminopyrimidine-5-boronic acid, pinacol esterHCID 866154406'-Bromo-6-methyl-4-(4-trifluoromethylphenyl)-[2,2']bipyridinyl

Product 1

HCID 247603585-[6'-Methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-pyrimidin-2-ylamine

Sources & evidence

ORD record
ord-ad460bb3e74b44c789d6ac4d82168aa1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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