Dichloromethane → Ethyl [4-(1-fluoro-2-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}ethyl)-2-methylphenoxy]acetate

HRID 1202090Notes

Reaction equation

HRID 1202090 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][N:5]([S:6]([F:7])([F:8])[F:11])[CH2:9][CH2:10][O:12][CH3:13].[Cl:47][CH2:48][Cl:49].[OH:14][CH:15]([CH2:16][c:17]1[c:18]([CH3:32])[n:19][c:20](-[c:22]2[cH:23][cH:24][c:25]([C:28]([F:29])([F:30])[F:31])[cH:26][cH:27]2)[s:21]1)[c:33]1[cH:34][c:35]([CH3:46])[c:36]([O:37][CH2:38][C:39](=[O:40])[O:41][CH2:42][CH3:43])[cH:44][cH:45]1>>[F:11][CH:15]([CH2:16][c:17]1[c:18]([CH3:32])[n:19][c:20](-[c:22]2[cH:23][cH:24][c:25]([C:28]([F:29])([F:30])[F:31])[cH:26][cH:27]2)[s:21]1)[c:33]1[cH:34][c:35]([CH3:46])[c:36]([O:37][CH2:38][C:39](=[O:40])[O:41][CH2:42][CH3:43])[cH:44][cH:45]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 2734690(Bis(2-methoxyethyl)amino)sulfur trifluorideHCID 17972190Ethyl [4-(1-hydroxy-2-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}ethyl)-2-methylphenoxy]acetate

Product 1

HCID 17972193Ethyl [4-(1-fluoro-2-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}ethyl)-2-methylphenoxy]acetate

Sources & evidence

ORD record
ord-cd4822f409814961ad94f9cce7d79e2f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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