Toluene → 3-{2-[4-(6-Fluorobenzo[d]isoxazol-3-yl)-piperidin-1-yl]-vinyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one

HRID 1202146Notes

Reaction equation

HRID 1202146 reaction equation
[CH3:1][c:2]1[n:3][c:4]2[n:5]([c:6](=[O:11])[c:7]1[CH2:8][CH:9]=[O:10])[CH2:12][CH2:13][CH2:14][CH2:15]2.[CH3:32][c:33]1[cH:34][cH:35][cH:36][cH:37][cH:38]1.[F:16][c:17]1[cH:18][c:19]2[c:20]([c:21]([CH:24]3[CH2:25][CH2:26][NH:27][CH2:28][CH2:29]3)[n:22][o:23]2)[cH:30][cH:31]1>>[CH3:1][c:2]1[n:3][c:4]2[n:5]([c:6](=[O:11])[c:7]1[CH:8]=[CH:9][N:27]1[CH2:26][CH2:25][CH:24]([c:21]3[c:20]4[c:19]([cH:18][c:17]([F:16])[cH:31][cH:30]4)[o:23][n:22]3)[CH2:29][CH2:28]1)[CH2:12][CH2:13][CH2:14][CH2:15]2

Participants

4

Reactant 3

HCID 1140TolueneHCID 8494213-(4-Piperidyl)-6-fluoro-1,2-benzisoxazoleHCID 102144672-(2-Methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-3-yl)acetaldehyde

Product 1

HCID 865989853-{2-[4-(6-Fluorobenzo[d]isoxazol-3-yl)-piperidin-1-yl]-vinyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one

Sources & evidence

ORD record
ord-5794975102bc4da7aa1be07a70cfa8ec
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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