8-(4-amino-3-fluorophenoxy)pyrido[2,3-b]pyrazin-3(4H)-one → 1-(2-Fluoro-4-(3-oxo-3,4-dihydropyrido[3,2-b]pyrazin-8-yloxy)phenyl)-3-(2-(pyridin-3-yloxy)-5-(trifluoromethyl)phenyl)urea
Reaction equation
[NH2:1][c:2]1[c:3]([F:20])[cH:4][c:5]([O:6][c:7]2[cH:8][cH:9][n:10][c:11]3[nH:12][c:13](=[O:17])[cH:14][n:15][c:16]23)[cH:18][cH:19]1.[n:21]1[cH:22][c:23]([O:27][c:28]2[c:29]([NH:38][C:39]([O:40][c:42]3[cH:43][cH:44][cH:45][cH:46][cH:47]3)=[O:41])[cH:30][c:31]([C:34]([F:35])([F:36])[F:37])[cH:32][cH:33]2)[cH:24][cH:25][cH:26]1>>[NH:1]([c:2]1[c:3]([F:20])[cH:4][c:5]([O:6][c:7]2[cH:8][cH:9][n:10][c:11]3[nH:12][c:13](=[O:17])[cH:14][n:15][c:16]23)[cH:18][cH:19]1)[C:39]([NH:38][c:29]1[c:28]([O:27][c:23]2[cH:22][n:21][cH:26][cH:25][cH:24]2)[cH:33][cH:32][c:31]([C:34]([F:35])([F:36])[F:37])[cH:30]1)=[O:40]Participants
3
Sources & evidence
- ORD record
- ord-4fb4e2b40b2e45edaf29bf2aa89f5aa9
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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