Water → tert-butyl (3RS,4RS)-4-(3-bromophenyl)-3-hydroxy-piperidine-1-carboxylate

HRID 1202602Notes

Reaction equation

HRID 1202602 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([c:14]2[cH:15][c:16]([Br:20])[cH:17][cH:18][cH:19]2)=[CH:12][CH2:13]1.[CH3:21][C:22]#[N:23].[OH2:24]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[cH:15][c:16]([Br:20])[cH:17][cH:18][cH:19]2)[CH:12]([OH:24])[CH2:13]1

Participants

4

Reactant 3

HCID 962WaterHCID 6342AcetonitrileHCID 66836951tert-butyl 4-(3-bromophenyl)-3,6-dihydropyridine-1(2H)-carboxylate

Product 1

HCID 54497878tert-butyl (3RS,4RS)-4-(3-bromophenyl)-3-hydroxy-piperidine-1-carboxylate

Sources & evidence

ORD record
ord-4d5986036f7345a793d22970023520f9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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