3,4-Dichlorobenzeneboronic acid → (1-(3,4-dichlorophenyl)-5-(1-isopropylpiperidin-4-yloxy)-1H-indol-2-yl)(4,4-difluoropiperidin-1-yl)methanone

HRID 1202963Notes

Reaction equation

HRID 1202963 reaction equation
[Cl:30][c:31]1[cH:32][c:33]([B:38]([OH:39])[OH:40])[cH:34][cH:35][c:36]1[Cl:37].[F:1][C:2]1([F:29])[CH2:3][CH2:4][N:5]([C:8](=[O:9])[c:10]2[nH:11][c:12]3[cH:13][cH:14][c:15]([O:19][CH:20]4[CH2:21][CH2:22][N:23]([CH:26]([CH3:27])[CH3:28])[CH2:24][CH2:25]4)[cH:16][c:17]3[cH:18]2)[CH2:6][CH2:7]1>>[F:1][C:2]1([F:29])[CH2:3][CH2:4][N:5]([C:8](=[O:9])[c:10]2[n:11](-[c:33]3[cH:32][c:31]([Cl:30])[c:36]([Cl:37])[cH:35][cH:34]3)[c:12]3[cH:13][cH:14][c:15]([O:19][CH:20]4[CH2:21][CH2:22][N:23]([CH:26]([CH3:27])[CH3:28])[CH2:24][CH2:25]4)[cH:16][c:17]3[cH:18]2)[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 27343303,4-Dichlorobenzeneboronic acidHCID 11603838(4,4-Difluoropiperidin-1-yl)[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]methanone

Product 1

HCID 16739525(1-(3,4-dichlorophenyl)-5-(1-isopropylpiperidin-4-yloxy)-1H-indol-2-yl)(4,4-difluoropiperidin-1-yl)methanone

Sources & evidence

ORD record
ord-e9abb64c46704ec0856e210113023e18
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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