Cyclopentanone → 8-(1-Hydroxy-cyclopentylmethanesulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one
Reaction equation
[CH3:1][S:2](=[O:3])(=[O:4])[N:5]1[CH2:6][CH2:7][C:8]2([CH2:9][CH2:10][N:11]([c:14]3[cH:15][cH:16][c:17]([O:20][C:21]([F:22])([F:23])[F:24])[cH:18][cH:19]3)[C:12]2=[O:13])[CH2:25][CH2:26]1.[O:27]=[C:28]1[CH2:29][CH2:30][CH2:31][CH2:32]1>>[CH2:1]([S:2](=[O:3])(=[O:4])[N:5]1[CH2:6][CH2:7][C:8]2([CH2:9][CH2:10][N:11]([c:14]3[cH:15][cH:16][c:17]([O:20][C:21]([F:22])([F:23])[F:24])[cH:18][cH:19]3)[C:12]2=[O:13])[CH2:25][CH2:26]1)[C:28]1([OH:27])[CH2:29][CH2:30][CH2:31][CH2:32]1Participants
3
Sources & evidence
- ORD record
- ord-68117348cb5c4132af73735dab9fdf17
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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