Toluene → N-tert-butyl-3-[6'-(tetrahydro-pyran-2-yloxymethyl)-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzenesulfonamide

HRID 1203219Notes

Reaction equation

HRID 1203219 reaction equation
[Br:1][c:2]1[n:3][c:4]([CH2:18][O:19][CH:20]2[O:21][CH2:22][CH2:23][CH2:24][CH2:25]2)[cH:5][c:6](-[c:8]2[cH:9][cH:10][c:11]([C:14]([F:15])([F:16])[F:17])[cH:12][cH:13]2)[cH:7]1.[C:26]([CH3:27])([CH3:28])([CH3:29])[NH:30][S:31](=[O:32])(=[O:33])[c:34]1[cH:35][c:36](-[c:40]2[n:41][c:42]([Sn:46]([CH2:47][CH2:48][CH2:49][CH3:50])([CH2:51][CH2:52][CH2:53][CH3:54])[CH2:55][CH2:56][CH2:57][CH3:58])[cH:43][cH:44][cH:45]2)[cH:37][cH:38][cH:39]1.[CH3:59][c:60]1[cH:61][cH:62][cH:63][cH:64][cH:65]1>>[c:2]1(-[c:42]2[n:41][c:40](-[c:36]3[cH:35][c:34]([S:31]([NH:30][C:26]([CH3:27])([CH3:28])[CH3:29])(=[O:32])=[O:33])[cH:39][cH:38][cH:37]3)[cH:45][cH:44][cH:43]2)[n:3][c:4]([CH2:18][O:19][CH:20]2[O:21][CH2:22][CH2:23][CH2:24][CH2:25]2)[cH:5][c:6](-[c:8]2[cH:9][cH:10][c:11]([C:14]([F:15])([F:16])[F:17])[cH:12][cH:13]2)[cH:7]1

Participants

4

Reactant 3

HCID 1140TolueneHCID 574686982-Bromo-6-(tetrahydro-pyran-2-yloxymethyl)-4-(4-trifluoromethyl-phenyl)-pyridineHCID 60209340HCID 60209340, compound

Product 1

HCID 68692639N-tert-butyl-3-[6'-(tetrahydro-pyran-2-yloxymethyl)-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzenesulfonamide

Sources & evidence

ORD record
ord-daeb08bd9d5b4f2781615e33a3d12a49
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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