Thionyl Chloride → (+/-)-6-[[4-(chloromethyl)phenyl]hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-4(3-chlorophenyl)-1-methyl-2(1H)-quinolinone

HRID 1203330Notes

Reaction equation

HRID 1203330 reaction equation
[Cl:1][c:2]1[cH:3][c:4](-[c:8]2[cH:9][c:10](=[O:35])[n:11]([CH3:34])[c:12]3[cH:13][cH:14][c:15]([C:18]([c:19]4[cH:20][n:21][cH:22][n:23]4[CH3:24])([c:25]4[cH:26][cH:27][c:28]([CH2:31][OH:32])[cH:29][cH:30]4)[OH:33])[cH:16][c:17]23)[cH:5][cH:6][cH:7]1.[S:36]([Cl:37])([Cl:38])=[O:39]>>[Cl:1][c:2]1[cH:3][c:4](-[c:8]2[cH:9][c:10](=[O:35])[n:11]([CH3:34])[c:12]3[cH:13][cH:14][c:15]([C:18]([c:19]4[cH:20][n:21][cH:22][n:23]4[CH3:24])([c:25]4[cH:26][cH:27][c:28]([CH2:31][Cl:38])[cH:29][cH:30]4)[OH:33])[cH:16][c:17]23)[cH:5][cH:6][cH:7]1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 10140969(+/-)-4-(3-chlorophenyl)-6-[hydroxy[4-(hydroxymethyl)phenyl](1-methyl-1H-imidazol-5-yl)methyl]-1-methyl-2(1H)-quinolinone

Product 1

HCID 21082106(+/-)-6-[[4-(chloromethyl)phenyl]hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-4(3-chlorophenyl)-1-methyl-2(1H)-quinolinone

Sources & evidence

ORD record
ord-a9ec5619a447463a956d1eac5e5901d5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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