1H-indole-6-carboxylic acid → 1H-indole-6-carboxylic acid (4-{2-oxo-2-[4-(2-oxo-2-pyrrolidin-1-yl-ethyl)-piperazin-1-yl]-ethyl}-thiazol-2-yl)-amide

HRID 1203366Notes

Reaction equation

HRID 1203366 reaction equation
[NH2:1][c:2]1[s:3][cH:4][c:5]([CH2:7][C:8](=[O:9])[N:10]2[CH2:11][CH2:12][N:13]([CH2:16][C:17]([N:18]3[CH2:19][CH2:20][CH2:21][CH2:22]3)=[O:23])[CH2:14][CH2:15]2)[n:6]1.[nH:24]1[cH:25][cH:26][c:27]2[cH:28][cH:29][c:30]([C:33](=[O:34])[OH:35])[cH:31][c:32]12>>[NH:1]([c:2]1[s:3][cH:4][c:5]([CH2:7][C:8](=[O:9])[N:10]2[CH2:11][CH2:12][N:13]([CH2:16][C:17]([N:18]3[CH2:19][CH2:20][CH2:21][CH2:22]3)=[O:23])[CH2:14][CH2:15]2)[n:6]1)[C:33]([c:30]1[cH:29][cH:28][c:27]2[cH:26][cH:25][nH:24][c:32]2[cH:31]1)=[O:34]

Participants

3

Reactant 2

HCID 5952301H-indole-6-carboxylic acidHCID 596988402-(2-Amino-thiazol-4-yl)-1-[4-(2-oxo-2-pyrrolidin-1-yl-ethyl)-piperazin-1-yl]-ethanone

Product 1

HCID 596988301H-indole-6-carboxylic acid (4-{2-oxo-2-[4-(2-oxo-2-pyrrolidin-1-yl-ethyl)-piperazin-1-yl]-ethyl}-thiazol-2-yl)-amide

Sources & evidence

ORD record
ord-25ce7ea497cf4cf6b127a3d22bd8a6bc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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