Pyridine → N-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)-6-methoxyphenyl]-3-(2,2-dimethyl-1,3-dioxolan-4-yl)prop-1-ene-2-sulfonamide

HRID 120513Notes

Reaction equation

HRID 120513 reaction equation
[CH3:1][C:2]1([CH3:14])[O:3][CH2:4][CH:5]([CH2:7][C:8](=[CH2:9])[S:10](=[O:11])(=[O:12])[Cl:13])[O:6]1.[F:15][c:16]1[cH:17][c:18]([O:33][CH3:34])[c:19]([NH2:32])[c:20]([NH:23][c:24]2[c:25]([F:31])[cH:26][c:27]([I:30])[cH:28][cH:29]2)[c:21]1[F:22].[cH:35]1[cH:36][cH:37][n:38][cH:39][cH:40]1>>[CH3:1][C:2]1([CH3:14])[O:3][CH2:4][CH:5]([CH2:7][C:8](=[CH2:9])[S:10](=[O:11])(=[O:12])[NH:32][c:19]2[c:18]([O:33][CH3:34])[cH:17][c:16]([F:15])[c:21]([F:22])[c:20]2[NH:23][c:24]2[c:25]([F:31])[cH:26][c:27]([I:30])[cH:28][cH:29]2)[O:6]1

Participants

4

Reactant 3

HCID 1049PyridineHCID 532609665,6-difluoro-N1-(2-fluoro-4-iodophenyl)-3-methoxybenzene-1,2-diamineHCID 755803843-(2,2-Dimethyl-1,3-dioxolan-4-yl)prop-1-ene-2-sulfonyl chloride

Product 1

HCID 87178508N-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)-6-methoxyphenyl]-3-(2,2-dimethyl-1,3-dioxolan-4-yl)prop-1-ene-2-sulfonamide

Sources & evidence

ORD record
ord-d5003c1810ee4ab6ae9826145cb9b5a4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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