tert-butyl N-[2-amino-4-[2-(4-fluorophenyl)ethynyl]-5-[(2-methylpropan-2-yl)oxy]phenyl]carbamate → tert-butyl N-[4-[2-(4-fluorophenyl)ethynyl]-2-[[3-(3-imidazol-1-ylphenyl)-3-oxopropanoyl]amino]-5-[(2-methylpropan-2-yl)oxy]phenyl]carbamate
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][c:8]1[c:9]([NH2:28])[cH:10][c:11]([C:19]#[C:20][c:21]2[cH:22][cH:23][c:24]([F:27])[cH:25][cH:26]2)[c:12]([O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[cH:13]1)=[O:29].[C:30]([CH3:32])([CH3:33])([O:34][C:35](=[O:31])[CH2:36][C:37](=[O:38])[c:39]1[cH:40][c:41](-[n:45]2[cH:46][n:47][cH:48][cH:49]2)[cH:42][cH:43][cH:44]1)[CH3:50]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][c:8]1[c:9]([NH:28][C:35](=[O:34])[CH2:36][C:37](=[O:38])[c:39]2[cH:40][c:41](-[n:45]3[cH:46][n:47][cH:48][cH:49]3)[cH:42][cH:43][cH:44]2)[cH:10][c:11]([C:19]#[C:20][c:21]2[cH:22][cH:23][c:24]([F:27])[cH:25][cH:26]2)[c:12]([O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[cH:13]1)=[O:29]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-5d7aa8a784444f36aea8805167fda06d
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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