tert-Butyl 4-oxopiperidine-1-carboxylate → N-Boc-7-bromo-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]

HRID 1205223Notes

Reaction equation

HRID 1205223 reaction equation
[Br:1][c:2]1[cH:3][c:4]([OH:11])[c:5]([C:8]([CH3:9])=[O:10])[cH:6][cH:7]1.[C:12](=[O:13])([O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[N:19]1[CH2:20][CH2:21][C:22](=[O:25])[CH2:23][CH2:24]1.[CH3:26][O:27][C:28](=[O:29])[CH:30]=[CH:31][c:32]1[cH:33][c:34]2[c:35]([cH:36][cH:37]1)[O:38][C:39]1([CH2:40][CH2:41][NH:42][CH2:43][CH2:44]1)[CH2:45][C:46]2=[O:47]>>[Br:1][c:2]1[cH:3][c:4]2[c:5]([cH:6][cH:7]1)[C:8](=[O:10])[CH2:9][C:22]1([O:11]2)[CH2:21][CH2:20][N:19]([C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[CH2:24][CH2:23]1

Participants

4

Reactant 3

HCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 107274031-(4-Bromo-2-hydroxyphenyl)ethan-1-oneHCID 66932212methyl 3-(4-oxospiro[3H-chromene-2,4'-piperidine]-6-yl)prop-2-enoate

Product 1

HCID 27281806N-Boc-7-bromo-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]

Sources & evidence

ORD record
ord-0cd8c1f4bb0e40b4ac273d0fe01bab9c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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