Methanol → [3-(Tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-benzyl]-(2,2-difluoro-ethyl)-amine
Reaction equation
[BH4-:24].[C:6]([CH3:7])([CH3:8])([CH3:9])[SiH2:10][O:11][C:12]([c:13]1[cH:14][c:15]([CH:16]=[O:17])[cH:18][cH:19][c:20]1[Cl:21])([CH3:22])[CH3:23].[CH3:26][OH:27].[F:1][CH:2]([CH2:3][NH2:4])[F:5].[Na+:25]>>[F:1][CH:2]([CH2:3][NH:4][CH2:16][c:15]1[cH:14][c:13]([C:12]([O:11][SiH2:10][C:6]([CH3:7])([CH3:8])[CH3:9])([CH3:22])[CH3:23])[c:20]([Cl:21])[cH:19][cH:18]1)[F:5]Participants
6
Sources & evidence
- ORD record
- ord-8cd95c22b184448a95d307cc7bc13fbb
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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