2-[Tert-butyl(diphenyl)silyl]oxybutanoic acid → 1-[2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-2-phenyl-1,3,4-thiadiazol-3-yl]-2-methoxybutan-1-one
Reaction equation
[C:1]([Si:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)([c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[O:15][CH:16]([CH2:17][CH3:18])[C:19]([OH:20])=[O:21])([CH3:22])([CH3:23])[CH3:24].[NH2:25][CH2:26][CH2:27][CH2:28][C:29]1([c:48]2[cH:49][cH:50][cH:51][cH:52][cH:53]2)[S:30][C:31]([c:40]2[c:41]([F:47])[cH:42][cH:43][c:44]([F:46])[cH:45]2)=[N:32][N:33]1[C:34]([CH:35]([CH3:36])[O:37][CH3:38])=[O:39]>>[CH3:1][CH2:36][CH:35]([C:34]([N:33]1[C:29]([CH2:28][CH2:27][CH2:26][NH2:25])([c:48]2[cH:49][cH:50][cH:51][cH:52][cH:53]2)[S:30][C:31]([c:40]2[c:41]([F:47])[cH:42][cH:43][c:44]([F:46])[cH:45]2)=[N:32]1)=[O:39])[O:37][CH3:38]Participants
3
Sources & evidence
- ORD record
- ord-eacb488a22ed46e495ac769fdedf591c
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
Loading…