Toluene → 5-(3-Fluorophenylethynyl)-pyridine-3-carbaldehyde

HRID 1205867Notes

Reaction equation

HRID 1205867 reaction equation
[CH2:2]([Al+:3][CH2:4][CH:5]([CH3:6])[CH3:7])[CH:8]([CH3:9])[CH3:10].[CH3:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1.[F:18][c:19]1[cH:20][c:21]([C:25]#[C:26][c:27]2[cH:28][n:29][cH:30][c:31]([C:32](=[O:33])[N:34]([O:35][CH3:36])[CH3:37])[cH:38]2)[cH:22][cH:23][cH:24]1.[H-:1]>>[F:18][c:19]1[cH:20][c:21]([C:25]#[C:26][c:27]2[cH:28][n:29][cH:30][c:31]([CH:32]=[O:33])[cH:38]2)[cH:22][cH:23][cH:24]1

Participants

5

Reactant 4

HCID 1140TolueneHCID 166653HydrideHCID 16686348Bis(2-methylpropyl)alumanyliumHCID 866224675-(3-Fluorophenylethynyl)-N-methoxy-N-methylnicotinamide

Product 1

HCID 860764545-(3-Fluorophenylethynyl)-pyridine-3-carbaldehyde

Sources & evidence

ORD record
ord-572e0adff8cc4b36bc928d7d44e7d839
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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