Acetonitrile → 3-bromo-5'-chloro-2'-fluoro-N-((tetrahydro-2H-pyran-4-yl)methyl)-2,4'-bipyridin-6-amine
Reaction equation
[Br:23][N:24]1[C:25](=[O:26])[CH2:27][CH2:28][C:29]1=[O:30].[CH3:31][C:32]#[N:33].[Cl:1][c:2]1[c:3](-[c:9]2[n:10][c:11]([NH:15][CH2:16][CH:17]3[CH2:18][CH2:19][O:20][CH2:21][CH2:22]3)[cH:12][cH:13][cH:14]2)[cH:4][c:5]([F:8])[n:6][cH:7]1>>[Cl:1][c:2]1[c:3](-[c:9]2[n:10][c:11]([NH:15][CH2:16][CH:17]3[CH2:18][CH2:19][O:20][CH2:21][CH2:22]3)[cH:12][cH:13][c:14]2[Br:23])[cH:4][c:5]([F:8])[n:6][cH:7]1Participants
4
Sources & evidence
- ORD record
- ord-a4cdb76e5f934ab28389c29291530ba7
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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