N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}2-methylpropanamide → 4-(2,4-Difluorophenyl)-N-(3-{4-[3-(isobutyrylamino)phenyl]-1-piperidinyl}propyl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxamide

HRID 1206570Notes

Reaction equation

HRID 1206570 reaction equation
[F:1][c:2]1[c:3]([CH:9]2[C:10]([C:17](=[O:18])[OH:19])=[C:11]([CH3:16])[NH:12][C:13](=[O:15])[CH2:14]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1.[NH2:20][CH2:21][CH2:22][CH2:23][N:24]1[CH2:25][CH2:26][CH:27]([c:30]2[cH:31][c:32]([NH:36][C:37]([CH:38]([CH3:39])[CH3:40])=[O:41])[cH:33][cH:34][cH:35]2)[CH2:28][CH2:29]1>>[F:1][c:2]1[c:3]([CH:9]2[C:10]([C:17](=[O:19])[NH:20][CH2:21][CH2:22][CH2:23][N:24]3[CH2:25][CH2:26][CH:27]([c:30]4[cH:31][c:32]([NH:36][C:37]([CH:38]([CH3:39])[CH3:40])=[O:41])[cH:33][cH:34][cH:35]4)[CH2:28][CH2:29]3)=[C:11]([CH3:16])[NH:12][C:13](=[O:15])[CH2:14]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1

Participants

3

Reactant 2

HCID 16757470N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}2-methylpropanamideHCID 220489194-(2,4-Difluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylic acid

Product 1

HCID 220494524-(2,4-Difluorophenyl)-N-(3-{4-[3-(isobutyrylamino)phenyl]-1-piperidinyl}propyl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxamide

Sources & evidence

ORD record
ord-d00b6f4bba1c4502b0ce25dc984b9374
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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