4-(Difluoromethoxy)benzyl Bromide → N-benzyl-2-(3-(4-(difluoromethoxy)benzyl)-2-oxopyrrolidin-1-yl)-4-methylthiazole-5-carboxamide
Reaction equation
[Br:23][CH2:24][c:25]1[cH:26][cH:27][c:28]([O:31][CH:32]([F:33])[F:34])[cH:29][cH:30]1.[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[NH:8][C:9](=[O:10])[c:11]1[c:12]([CH3:22])[n:13][c:14]([N:16]2[C:17](=[O:21])[CH2:18][CH2:19][CH2:20]2)[s:15]1>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[NH:8][C:9](=[O:10])[c:11]1[c:12]([CH3:22])[n:13][c:14]([N:16]2[C:17](=[O:21])[CH:18]([CH2:24][c:25]3[cH:26][cH:27][c:28]([O:31][CH:32]([F:33])[F:34])[cH:29][cH:30]3)[CH2:19][CH2:20]2)[s:15]1Participants
3
Sources & evidence
- ORD record
- ord-c6a66b43ddcb439ba54f6a32955356b6
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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