Methanol → 6-chloro-4'-(3-chlorophenyl)-2'-(5-fluoro-2-methylphenyl)-1'-methyl spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

HRID 1206704Notes

Reaction equation

HRID 1206704 reaction equation
[CH3:37][OH:38].[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:9]([cH:10]1)[N:8]([CH2:11][CH2:12][OH:13])[C:7](=[O:14])[C:6]21[CH:15]([c:29]2[c:30]([CH3:36])[cH:31][cH:32][c:33]([F:35])[cH:34]2)[N:16]([CH3:28])[C:17](=[O:27])[CH2:18][CH:19]1[c:20]1[cH:21][c:22]([Cl:26])[cH:23][cH:24][cH:25]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:9]([cH:10]1)[NH:8][C:7](=[O:14])[C:6]21[CH:15]([c:29]2[c:30]([CH3:36])[cH:31][cH:32][c:33]([F:35])[cH:34]2)[N:16]([CH3:28])[C:17](=[O:27])[CH2:18][CH:19]1[c:20]1[cH:21][c:22]([Cl:26])[cH:23][cH:24][cH:25]1

Participants

3

Reactant 2

HCID 887MethanolHCID 775810676-Chloro-4'-(3-chlorophenyl)-2'-(5-fluoro-2-methylphenyl)-2,3-dihydro-1'-methyl-2,6'-dioxo spiro[indole-3,3'-piperidine]-1-ethanol

Product 1

HCID 775808366-chloro-4'-(3-chlorophenyl)-2'-(5-fluoro-2-methylphenyl)-1'-methyl spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

Sources & evidence

ORD record
ord-5d9b961a9f604294a7a74f270e81fb8e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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