Methanol → Tert-butyl 2-[(3-chloroanilino)methyl]-4,4-difluoropyrrolidine-1-carboxylate
Reaction equation
[BH4-:25].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([CH:15]=[O:16])[CH2:10][C:11]([F:13])([F:14])[CH2:12]1.[CH3:27][CH:28]([CH3:29])[O-:30].[CH3:31][CH:32]([CH3:33])[O-:34].[CH3:35][CH:36]([CH3:37])[O-:38].[CH3:39][CH:40]([CH3:41])[O-:42].[CH3:44][OH:45].[Cl:17][c:18]1[cH:19][c:20]([NH2:21])[cH:22][cH:23][cH:24]1.[Na+:26].[Ti+4:43]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([CH2:15][NH:21][c:20]2[cH:19][c:18]([Cl:17])[cH:24][cH:23][cH:22]2)[CH2:10][C:11]([F:13])([F:14])[CH2:12]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-a9befa082795426f8af1de1d83c8c868
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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