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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1206841Generated: November 2, 2026

Dimethylformamide → racemic (2'S,3S,4'R)-1'-(aminocarbonyl-methyl)-6-chloro-2'-(3-chlorophenyl)-4'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

https://huagongshe.com/reaction/1206841

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethylformamideHCID 6228—
ReactantDichloromethaneHCID 6344—
ReactantTrifluoroacetic acidHCID 6422—
ReactantCarbonate IonHCID 19660—
Reactant2-BromoacetamideHCID 69632—
ReactantCesium cationHCID 104967—
Reactant(1-Methoxyethyl)(trimethyl)silaneHCID 22400412—
Reactantracemic (2'S,3S,4'R)-6-chloro-2'-(3-chlorophenyl)-4'-(5-fluoro-2-methyl-phenyl)-spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dioneHCID 76568090—
Productracemic (2'S,3S,4'R)-1'-(aminocarbonyl-methyl)-6-chloro-2'-(3-chlorophenyl)-4'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dioneHCID 76568085—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (5/10)
ORD IDord-83da5967d993470b96631b85418e6a25
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (5/10)