1,4-Dioxane → 6-(7-(2-Fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)nicotinaldehyde

HRID 1207618Notes

Reaction equation

HRID 1207618 reaction equation
[Br:22][c:23]1[n:24][cH:25][c:26]([CH:27]=[O:28])[cH:29][cH:30]1.[CH2:31]1[O:32][CH2:33][CH2:34][O:35][CH2:36]1.[F:1][c:2]1[c:3]([O:4][c:5]2[c:6]3[c:7]([n:8][cH:9][cH:10]2)[cH:11][c:12]([I:14])[s:13]3)[cH:15][cH:16][c:17]([N+:19](=[O:20])[O-:21])[cH:18]1.[cH:37]1[cH:38][cH:39][c:40]([P:41]([Pd:42]([P:43]([c:44]2[cH:45][cH:46][cH:47][cH:48][cH:49]2)([c:50]2[cH:51][cH:52][cH:53][cH:54][cH:55]2)[c:56]2[cH:57][cH:58][cH:59][cH:60][cH:61]2)([P:62]([c:63]2[cH:64][cH:65][cH:66][cH:67][cH:68]2)([c:69]2[cH:70][cH:71][cH:72][cH:73][cH:74]2)[c:75]2[cH:76][cH:77][cH:78][cH:79][cH:80]2)[P:81]([c:82]2[cH:83][cH:84][cH:85][cH:86][cH:87]2)([c:88]2[cH:89][cH:90][cH:91][cH:92][cH:93]2)[c:94]2[cH:95][cH:96][cH:97][cH:98][cH:99]2)([c:100]2[cH:101][cH:102][cH:103][cH:104][cH:105]2)[c:106]2[cH:107][cH:108][cH:109][cH:110][cH:111]2)[cH:112][cH:113]1>>[F:1][c:2]1[c:3]([O:4][c:5]2[c:6]3[c:7]([n:8][cH:9][cH:10]2)[cH:11][c:12](-[c:23]2[n:24][cH:25][c:26]([CH:27]=[O:28])[cH:29][cH:30]2)[s:13]3)[cH:15][cH:16][c:17]([N+:19](=[O:20])[O-:21])[cH:18]1

Participants

5

Reactant 4

HCID 312751,4-DioxaneHCID 117692346-Bromo-3-pyridinecarboxaldehydeHCID 594576617-(2-Fluoro-4-nitrophenoxy)-2-iodothieno[3,2-b]pyridineHCID 178420554HCID 178420554, compound

Product 1

HCID 594576666-(7-(2-Fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)nicotinaldehyde

Sources & evidence

ORD record
ord-bfdb50ef4b514c7083de28793a84e239
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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