2-chloro-N-(1-(2,3-dihydroxypropyl)-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)-6H-thieno(2,3-b)pyrrole-5-carboxamide → 2-chloro-N-[1-[(2,2-dimethyl-1,3-dioxan-5-yl)methyl]-2-oxo-3,4-dihydroquinolin-3-yl]-6H-thieno[2,3-b]pyrrole-5-carboxamide

HRID 1208350Notes

Reaction equation

HRID 1208350 reaction equation
[Cl:22][c:23]1[cH:24][c:25]2[c:26]([nH:27][c:28]([C:30](=[O:31])[NH:32][CH:33]3[CH2:34][c:35]4[c:36]([cH:37][cH:38][cH:39][cH:40]4)[N:41]([CH2:42][CH:43]([OH:44])[CH2:45][OH:46])[C:47]3=[O:48])[cH:29]2)[s:49]1.[NH2:1][CH:2]1[C:3](=[O:21])[N:4]([CH2:12][CH:13]2[CH2:14][O:15][C:16]([CH3:19])([CH3:20])[O:17][CH2:18]2)[c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[CH2:11]1>>[NH:1]([CH:2]1[C:3](=[O:21])[N:4]([CH2:12][CH:13]2[CH2:14][O:15][C:16]([CH3:19])([CH3:20])[O:17][CH2:18]2)[c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[CH2:11]1)[C:30]([c:28]1[nH:27][c:26]2[c:25]([cH:24][c:23]([Cl:22])[s:49]2)[cH:29]1)=[O:31]

Participants

3

Reactant 2

HCID 117428502-chloro-N-(1-(2,3-dihydroxypropyl)-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)-6H-thieno(2,3-b)pyrrole-5-carboxamideHCID 219068303-amino-1-[(2,2-dimethyl-1,3-dioxan-5-yl)methyl]-3,4-dihydroquinolin-2(1H)-one

Product 1

HCID 104350132-chloro-N-[1-[(2,2-dimethyl-1,3-dioxan-5-yl)methyl]-2-oxo-3,4-dihydroquinolin-3-yl]-6H-thieno[2,3-b]pyrrole-5-carboxamide

Sources & evidence

ORD record
ord-e65cd99ba5824c79a6b1f81094c41f61
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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