HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → 4-[(2-Chloro-6-methylpyrimidin-4-yl)oxy]-2,5-dimethylaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-Amino-2,5-dimethylphenol | HCID 76544 | — |
| Reactant | 2,4-Dichloropyrimidine | HCID 77531 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-[(2-Chloro-6-methylpyrimidin-4-yl)oxy]-2,5-dimethylaniline | HCID 86628975 | — |
Reaction Steps
A solution of 4.53 g (33 mmol) 4-amino-2,5-dimethylphenol and 1.44 g NaOH (2M) in 30 ml water were added dropwise to a solution of 4.89 g (30.0 mmol) of 2,4-dichloropyrimidine in 50 ml of acetone. The reaction mixture was stirred for 20 h at ambient temperature.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07727986B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-a317305e306944ef82b1ad5a3fc53986 |
| Source note | uspto-grants-2010_06 |