Methanol → N-(4-fluorophenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine

HRID 1208844Notes

Reaction equation

HRID 1208844 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][c:10]2[c:11]([n:12][cH:13][n:14][c:15]2[NH:16][c:17]2[cH:18][cH:19][c:20]([F:23])[cH:21][cH:22]2)[CH2:24][CH2:25]1.[CH3:26][OH:27].[OH-:28].[OH-:30].[Pd+2:29]>>[NH:8]1[CH2:9][c:10]2[c:11]([n:12][cH:13][n:14][c:15]2[NH:16][c:17]2[cH:18][cH:19][c:20]([F:23])[cH:21][cH:22]2)[CH2:24][CH2:25]1

Participants

5

Reactant 4

HCID 887MethanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 593465676-Benzyl-N-(4-fluorophenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine

Product 1

HCID 59346533N-(4-fluorophenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine

Sources & evidence

ORD record
ord-9024d0bb7675464f8034ab54c26ad335
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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