Chlorotrimethylsilane → N-(4-(4-(5-aminopentylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)phenyl)-N-methylacetamide

HRID 1208880Notes

Reaction equation

HRID 1208880 reaction equation
[CH3:30][Si:31]([Cl:32])([CH3:33])[CH3:34].[NH2:18][c:19]1[cH:20][cH:21][c:22]([N:25]([C:26]([CH3:27])=[O:28])[CH3:29])[cH:23][cH:24]1.[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][NH:7][c:8]1[c:9]2[c:10]([n:11][c:12]([Cl:14])[n:13]1)[nH:15][cH:16][cH:17]2>>[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][NH:7][c:8]1[c:9]2[c:10]([n:11][c:12]([NH:18][c:19]3[cH:20][cH:21][c:22]([N:25]([C:26]([CH3:27])=[O:28])[CH3:29])[cH:23][cH:24]3)[n:13]1)[nH:15][cH:16][cH:17]2

Participants

4

Reactant 3

HCID 6397ChlorotrimethylsilaneHCID 67068N-(4-Aminophenyl)-N-methylacetamideHCID 86636620N-(5-aminopentyl)-2-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Product 1

HCID 57990326N-(4-(4-(5-aminopentylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)phenyl)-N-methylacetamide

Sources & evidence

ORD record
ord-27bb2fd781ae44a9bf87917d7253b97b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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