HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 8-{2-[1,1-dimethyl-2-(4-hydroxyphenyl)ethylamino]-1-hydroxyethyl}-6-benzyloxy-4H-benzo[1,4]oxazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Hydroxyphentermine | HCID 84139 | — |
| Reactant | (6-benzyloxy-4H-benzo[1,4]oxazin-3-one)-glyoxal hydrate | HCID 86593722 | — |
| Product | 8-{2-[1,1-dimethyl-2-(4-hydroxyphenyl)ethylamino]-1-hydroxyethyl}-6-benzyloxy-4H-benzo[1,4]oxazin-3-one | HCID 22063487 | — |
Reaction Steps
The title compound is prepared from 10 g of (6-benzyloxy-4H-benzo[1,4]oxazin-3-one)-glyoxal hydrate and 4.6 g of 1,1-dimethyl-2-(4-hydroxyphenyl)ethylamine analogously to the method for Example 3(a). Yield: 9.0 g (64%, hydrochloride); melting point: 255° C.-258° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07727984B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-6d605ae120b142b89b2218dc15bdf324 |
| Source note | uspto-grants-2010_06 |