Acetic Acid → Tert-butyl 2-(chloromethyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-1-ene-8-carboxylate

HRID 1209355Notes

Reaction equation

HRID 1209355 reaction equation
[CH3:27][C:28](=[O:29])[OH:30].[Cl:18][CH2:19][C:20]([O:21][CH3:22])([O:23][CH3:24])[O:25][CH3:26].[NH2:1][C:2]1([C:15]([NH2:16])=[O:17])[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1>>[N:1]1=[C:20]([CH2:19][Cl:18])[NH:16][C:15](=[O:17])[C:2]12[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]2

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 1447021,1,1-Trimethoxy-2-chloroethaneHCID 10562199tert-Butyl 4-amino-4-carbamoylpiperidine-1-carboxylate

Product 1

HCID 57908082Tert-butyl 2-(chloromethyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-1-ene-8-carboxylate

Sources & evidence

ORD record
ord-1f6705fea4ab4019a3bf8d137b70cf37
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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