Acetate → 2,3-Difluoro-5-(3-methylisothiazol-5-yl)pyridine

HRID 1209556Notes

Reaction equation

HRID 1209556 reaction equation
[CH2:20]1[O:21][CH2:22][CH2:23][O:24][CH2:25]1.[CH3:10][c:11]1[n:12][s:13][c:14]([Sn:16]([CH3:17])([CH3:18])[CH3:19])[cH:15]1.[Cl:1][c:2]1[cH:3][c:4]([F:9])[c:5]([F:8])[n:6][cH:7]1.[O-:27][C:28]([CH3:29])=[O:30].[O-:31][C:32]([CH3:33])=[O:34].[Pd+2:26]>>[c:2]1(-[c:14]2[s:13][n:12][c:11]([CH3:10])[cH:15]2)[cH:3][c:4]([F:9])[c:5]([F:8])[n:6][cH:7]1

Participants

6

Reactant 5

HCID 175Acetate2×HCID 312751,4-DioxaneHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 27832485-Chloro-2,3-difluoropyridineHCID 100383203-Methyl-5-(trimethylstannyl)isothiazole

Product 1

HCID 675028582,3-Difluoro-5-(3-methylisothiazol-5-yl)pyridine

Sources & evidence

ORD record
ord-9bcf56bded634a7faf106295371a7dd6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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