Toluene → 2-amino-8-ethyl-4-methyl-6-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7(8H)-one
Reaction equation
[CH2:17]([Sn:18]([CH2:19][CH2:20][CH2:21][CH3:27])([c:22]1[s:23][cH:24][cH:25][n:26]1)[CH2:28][CH2:29][CH2:30][CH3:31])[CH2:32][CH2:33][CH3:34].[CH3:35][c:36]1[cH:37][cH:38][cH:39][cH:40][cH:41]1.[NH2:1][c:2]1[n:3][c:4]([CH3:16])[c:5]2[c:6]([n:7]1)[n:8]([CH2:14][CH3:15])[c:9](=[O:13])[c:10]([Br:12])[cH:11]2.[cH:42]1[cH:43][cH:44][c:45]([P:46]([Pd:47]([P:48]([c:49]2[cH:50][cH:51][cH:52][cH:53][cH:54]2)([c:55]2[cH:56][cH:57][cH:58][cH:59][cH:60]2)[c:61]2[cH:62][cH:63][cH:64][cH:65][cH:66]2)([P:67]([c:68]2[cH:69][cH:70][cH:71][cH:72][cH:73]2)([c:74]2[cH:75][cH:76][cH:77][cH:78][cH:79]2)[c:80]2[cH:81][cH:82][cH:83][cH:84][cH:85]2)[P:86]([c:87]2[cH:88][cH:89][cH:90][cH:91][cH:92]2)([c:93]2[cH:94][cH:95][cH:96][cH:97][cH:98]2)[c:99]2[cH:100][cH:101][cH:102][cH:103][cH:104]2)([c:105]2[cH:106][cH:107][cH:108][cH:109][cH:110]2)[c:111]2[cH:112][cH:113][cH:114][cH:115][cH:116]2)[cH:117][cH:118]1>>[NH2:1][c:2]1[n:3][c:4]([CH3:16])[c:5]2[c:6]([n:7]1)[n:8]([CH2:14][CH3:15])[c:9](=[O:13])[c:10](-[c:22]1[s:23][cH:24][cH:25][n:26]1)[cH:11]2Participants
5
Sources & evidence
- ORD record
- ord-7d894dd95fa84ae3abaa3a0c977ac2c8
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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