反应详情

11.0 mL acetone, diluted with 50 mL diethyl ether, is added dropwise to a solution of 500 mL of 0.25 molar 2,4-difluorobenzylmagnesium bromide in diethyl ether within 20 minutes. Then the mixture is refluxed for 1.5 hours and then hydrolyzed with 10% ammonium chloride solution. The ether phase is separated off, washed with water, dried with sodium sulfate, and evaporated down. The fractional distillation of the residue yields the alcohol as a colorless liquid (boiling point: 70° C.-73° C./2 mmbar). Yield: 20.0 g (86%).

1. temperatureThen the mixture is refluxed for 1.5 hours
2. customThe ether phase is separated off
3. washwashed with water
4. dry with materialdried with sodium sulfate
5. customevaporated down
6. distillationThe fractional distillation of the residue