Diethyl Ether → 7-Benzyl-N-(4-(difluoromethoxy)phenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-amine

HRID 1210400Notes

Reaction equation

HRID 1210400 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][c:10]2[n:11][cH:12][n:13][c:14]([Cl:18])[c:15]2[CH2:16][CH2:17]1.[CH2:30]1[O:31][CH2:32][CH2:33][O:34][CH2:35]1.[CH3:36][CH2:37][O:38][CH2:39][CH3:40].[F:19][CH:20]([O:21][c:22]1[cH:23][cH:24][c:25]([NH2:28])[cH:26][cH:27]1)[F:29]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][c:10]2[n:11][cH:12][n:13][c:14]([NH:28][c:25]3[cH:24][cH:23][c:22]([O:21][CH:20]([F:19])[F:29])[cH:27][cH:26]3)[c:15]2[CH2:16][CH2:17]1

Participants

5

Reactant 4

HCID 3283Diethyl EtherHCID 312751,4-DioxaneHCID 7373634-(Difluoromethoxy)anilineHCID 219588387-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

Product 1

HCID 590215487-Benzyl-N-(4-(difluoromethoxy)phenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-amine

Sources & evidence

ORD record
ord-426df4699d93412b8210a446061a8160
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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