Acetate → 8-(2-Methoxypyridin-4-yl)-1,4-dioxa-8-azaspiro[4.5]decane

HRID 1210455Notes

Reaction equation

HRID 1210455 reaction equation
[CH3:45][C:46]([CH3:47])([O-:48])[CH3:49].[CH:1]1([P:2]([CH:3]2[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]2)[c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2-[c:15]2[cH:16][cH:17][cH:18][cH:19][cH:20]2)[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]1.[Cl:26][c:27]1[cH:28][c:29]([O:33][CH3:34])[n:30][cH:31][cH:32]1.[Na+:50].[O-:58][C:59]([CH3:60])=[O:61].[O-:62][C:63]([CH3:64])=[O:65].[O:35]1[CH2:36][CH2:37][O:38][C:39]12[CH2:40][CH2:41][NH:42][CH2:43][CH2:44]2.[O:51]1[CH2:52][CH2:53][O:54][CH2:55][CH2:56]1.[Pd+2:57]>>[c:27]1([N:42]2[CH2:41][CH2:40][C:39]3([O:35][CH2:36][CH2:37][O:38]3)[CH2:44][CH2:43]2)[cH:28][c:29]([O:33][CH3:34])[n:30][cH:31][cH:32]1

Participants

9

Reactant 8

HCID 175Acetate2×HCID 923Sodium ionHCID 312751,4-DioxaneHCID 674351,4-Dioxa-8-azaspiro(4.5)decaneHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 27342162-(Dicyclohexylphosphino)biphenylHCID 45749132-Methylpropan-2-olateHCID 226385104-Chloro-2-methoxypyridine

Product 1

HCID 673434058-(2-Methoxypyridin-4-yl)-1,4-dioxa-8-azaspiro[4.5]decane

Sources & evidence

ORD record
ord-8ffdba58c1cc4a648326d3de26fb6247
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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