Methanol → 5-fluoro-2-(1-(2-hydroxyethyl)-1H-indazol-5-yloxy)benzonitrile

HRID 1210991Notes

Reaction equation

[BH4-:25].[C:1](#[N:2])[c:3]1[c:4]([O:5][c:6]2[cH:7][c:8]3[cH:9][n:10][n:11]([CH2:15][C:16](=[O:17])[O:18][CH3:19])[c:12]3[cH:13][cH:14]2)[cH:20][cH:21][c:22]([F:24])[cH:23]1.[CH3:27][OH:28].[Na+:26]>>[C:1](#[N:2])[c:3]1[c:4]([O:5][c:6]2[cH:7][c:8]3[cH:9][n:10][n:11]([CH2:15][CH2:16][OH:17])[c:12]3[cH:13][cH:14]2)[cH:20][cH:21][c:22]([F:24])[cH:23]1

Participants

Reactant 4

HCID 887Methanol

HCID 923Sodium ion

HCID 28123Borohydride

HCID 57552286methyl 2-(5-(2-cyano-4-fluorophenoxy)-1H-indazol-1-yl)acetate

Product 1

HCID 445421215-fluoro-2-(1-(2-hydroxyethyl)-1H-indazol-5-yloxy)benzonitrile

Sources & evidence

ORD record: ord-8563fbb96ad840d988198a5409ae4079
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

Reaction notes

Loading…