HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → 1-(3,4-Difluorophenyl)-2-methylpropan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | 4-(Bromomethyl)-1,2-difluorobenzene | HCID 581436 | — |
| Product | 1-(3,4-Difluorophenyl)-2-methylpropan-2-ol | HCID 21744463 | — |
Reaction Steps
From 23.0 g (111 mmol) of 3,4-difluorobenzyl bromide a Grignard is prepared, which is then reacted with 11.6 mL (158 mmol) of acetone. Slightly yellow oil. Yield: 9.7 g (47%); Rf value: 0.55 (ethyl acetate-petroleum ether (1:3)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07727984B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-72dec086166f4873afdcae84023e3b58 |
| Source note | uspto-grants-2010_06 |